 |
 |
I am posting this on behalf of Dr Stephen Jolles, Consultant
Immunologist at UHW Cardiff.
Dear Dr Chakraborty,
Many thanks for your query which has been
passed to me as we have some ongoing projects on calculated globulin and
it’s potential utility as a screen for antibody deficiency. We have found
using the BCG method at a cut off of 18g/l that 89% of samples had an IgG of
less tha 6g/l. We are currently working on the cut off for the BCP method. We
found a number of causes of low CG including recent surgery, iv fluids in
hospital and ITU etc as well as a range of causes of secondary antibody
deficiency and some primary antibody deficiency. In addition we found
approximately 2% had new small paraproteins with immunoparesis. We are
currently looking at the possible introduction of an automated comment for GP
samples with CG <18g/l on the BCG method ‘Low calculated globulin – may represent antibody
deficiency. Consider immunoglobulins if there is a history of infection.’
Hope this is helpful with best wishes
Stephen
_________________________________
Dr Stephen Jolles
Consultant Clinical Immunologist
Department of Immunology
CF14 4XW
Tel : 029 2074 5814
Fax: 029 2074 8383
www.immunology.wales.nhs.uk
_________________________________
Cymraeg
Rhybudd Ebost (2010) - Bwrdd Iechyd Prifysgol Betsi Cadwaladr
Fe'ch cynghorir i ddarllen rhybydd ebost Bwrdd Iechyd Prifysgol
Betsi Cadwaladr (a'i
argraffu er mwyn cyfeirio ato yn y dyfodol). Gellir dod o hyd iddo yn y
lleoliad canlynol
http://www.wales.nhs.uk/sitesplus/861/tudalen/47230
English
Betsi Cadwaladr University Health Board - Email Notice
(2010)
You
are advised to read (and print for future reference) the Betsi Cadwaladr
University Health Board e-mail notice which can be found at this
location
Betsi Cadwaladr University Health Board is the operational name of
Betsi Cadwaladr University Local Health Board