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Hi - see the TBSS documentation and original NeuroImage paper;  the current default recommendation is to register all subjects directly to standard space template, unless you think you have an "unusual" study population, in which case you may want to go via a study-specific template.

Cheers.


On 18 Apr 2012, at 00:37, Jarrett, Mike wrote:

Hello experts,

In a study we are working on we plan on registering our subject DTI scans to standard space using FSL. Applying FLIRT and FNIRT in a two step process to each subject scan with the FMRIB58_FA scan as the reference seems to work quite well.

However, after reviewing the literature, many researchers using FSL seem to follow a procedure in which all subject scans are registered to a "typical" subject scan, which is then registered to standard space. The resulting transform is then applied to all the other scans to register them to standard space as well.

Is there a benefit to using this method? It looks like it could be faster (processor-wise) than registering each scan individually, but I'm not clear on whether or not it improves the quality of the registration. Any advice or references would be greatly appreciated -- I'm quite new to this.

Cheers,

Mike


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