Hi - yes - see the dual_regression page - your clinical scores should be demeaned and entered into the design that is fed to the randomise call. Cheers. On 28 Mar 2012, at 15:10, John wrote: > Hi Christian > Thank you for getting back to me...Sorry I wasn't clear earlier, coming from SPM I'm not sure of the terminologies. I did do a dual regression ICA analysis to look at connectivity, now I am trying to look at the effect of clinical values on these connectivity (such as pain). Should I enter the clinical scores as covariates? and do I demean them? > Thanks again, > John > --------------------------------------------------------------------------- Stephen M. Smith, Professor of Biomedical Engineering Associate Director, Oxford University FMRIB Centre FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK +44 (0) 1865 222726 (fax 222717) [log in to unmask] http://www.fmrib.ox.ac.uk/~steve ---------------------------------------------------------------------------