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Dear SPMs, I have a question concerning Psychophysiological (PPI). I have two groups and one (Group A) activates the inferior frontal gyrus (IFG) much more than the other. When I perform PPI having the IFG as seed, group A positive and negative connections are fewer and less strong than in group B. I wanted to explore why this is the case? How can explore if the variance in the BOLD activity in IFG in group A is really low, that could lead to reduced functional connectivity? Or is there anything else I should explore? Thank you very much in advance :) Any help is much appreciate it! Zoe