Does this persist when you make sure the FSLView has the same min and max (0 and 1) across all images? Peace, Matt. -----Original Message----- From: FSL - FMRIB's Software Library [mailto:[log in to unmask]] On Behalf Of Woodman, Sandra Sent: Friday, September 09, 2011 3:18 PM To: [log in to unmask] Subject: [FSL] DTI processing differences between 2008 and now? Hi all, We have encountered something with our DTI data and are wondering if anyone else has seen the same thing and if it has an impact on our data. We have been working on a DTI analysis dataset for a few years (a lot of methods development work went into this particular study), and we have recently noticed that the FA maps that were unpacked and preprocessed in October 2008 look, to the bare eye, brighter overall than those processed in October 2009 and later. We tried loading them into the freesurfer tkmedit tool and we did not see much of a difference, so we are wondering if this is simply a visualization issue. We realize that there may have been changes in the version of FSL during this time and/or the software programs themselves, and want to be sure that the data analyzed earlier has been treated in the same way as that which was analyzed later. In addition, we have run tractography on this dataset, and there seem to be more log files in the bedpostx log directory in the sessions that were run more recently. So we are also wondering if something has changed in the bedpostx program between October 2008 and October 2009 that affects the tractography data. Thank you! Sandra The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.