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Hi Sarika, I am not sure there is an answer to "the best method" for creating priors, but since we already publicly claimed that the idea of using a statistical approach to doing this is a good one, I also recommend it here: the TOM toolbox allows to generate priors using a general linear model approach, based on a reference population that you may preprocess as you see fit (for some hints, see the NI 2008 paper). The main problem with the paper is that we put "pediatric" in the title, although the approach is in no way restricted to children (in fact, I think it would be extremely interesting to assess the effects in, say, an elderly population). You will find more information and the toolbox itself on the IRC website at https://irc.cchmc.org/software/tom.php Cheers, Marko PS: I should have mentioned that the need for customized priors has become much less pressing with recent changes to the segmentation approach but since this is well-documented in the archives ... :) sarika cherodath wrote: > Hello SPMers, > > Does anyone know what the best available method for > creating priors is? Is it possible to generate priors from a large > enough data set of one's own? Many template creation tools provide > priors but they are derived based on a data set of their own.Is it > possible to make priors and templates only based on your population's > data, and based on a standard atlas of some kind? > > Thank you in advance, > -- > Sarika Cherodath > Graduate Student > National Brain Research Centre > Manesar, Gurgaon -122050 > India > -- ____________________________________________________ PD Dr. med. Marko Wilke Facharzt für Kinder- und Jugendmedizin Leiter, Experimentelle Pädiatrische Neurobildgebung Universitäts-Kinderklinik Abt. III (Neuropädiatrie) Marko Wilke, MD, PhD Pediatrician Head, Experimental Pediatric Neuroimaging University Children's Hospital Dept. III (Pediatric Neurology) Hoppe-Seyler-Str. 1 D - 72076 Tübingen, Germany Tel. +49 7071 29-83416 Fax +49 7071 29-5473 [log in to unmask] http://www.medizin.uni-tuebingen.de/kinder/epn ____________________________________________________