Dear Christopher, Thanks for the quick reply. I did some digging after posting and think that it is likely what I want is parametric modulation with order=0 (or is it one?). The analysis I want to perform can be summerised by this: 1. Using a mask, get the average value for an ROI for each time point 2. Put this value in as a condition in first level analysis. I think you and I have the same idea: Do a parametric modulation, i.e.: SPM.Session(s).U(i).P= struct('name', 'weight', 'P', <weights array>, 'h', '0', or on the SPM UI: Name, values and Polynomial Expansion respectively. I am using order 0 polynomial because we only have a weight, i.e., a constant. Is this the way to approach it? Many thanks in advance and best regards Cinly On 26 July 2011 21:48, Watson, Christopher < [log in to unmask]> wrote: > Are you talking about doing parametric modulations? What's your task? > ________________________________________ > From: SPM (Statistical Parametric Mapping) [[log in to unmask]] On Behalf > Of Cinly Ooi [[log in to unmask]] > Sent: Tuesday, July 26, 2011 3:28 PM > To: [log in to unmask] > Subject: [SPM] Varying the weight for 1st level design matrix > > Dear All, > > Someone asked me to run a first level analysis where instead of a standard > boxcar or event design, I have a weighting value associated with each TR. I > believe what I have to do is to set the onset time and duration as usual, > then assign a weight to each onset time.i.e., instead of accepting the > standard weight of '1,1,1,1', I want to specify them as '2,1,1,2' for > example. > > Since each session will have its own unique weights, for ease of data > entry, I will be reading the weights from files and will be processing the > data using Rhodri's AA. > > A bit of digging into AA shows that I have to setup this up using > SPM.Session(s), and I believe SPM.Session(s).U is the candidate to accept > the weights. My problem is, after reading spm_FMRI_design.m, I still have no > clue how to set the weight. > > How do I go about setting the weights? These weights are expected to be > convoluted with HRF later. > > In case it helps, it is one weight per volume. So since I have 224 volumes > in the fMRI time series, I will have 224 weights to put in. > > Many thanks in advance and hope to hear from you soon. > > Best Regards, > Cinly > > -- Best Regards, Cinly ***** Don't bother with footer please. I don't read them and will not be bounded by them. It cannot be enforced legally anyway. If it can, then remember this: This footer always triumph yours. -- Best Regards, Cinly ***** Don't bother with footer please. I don't read them and will not be bounded by them. It cannot be enforced legally anyway. If it can, then remember this: This footer always triumph yours.