Post-doctoral Fellows Peersen and Cohen Laboratories Department of Biochemistry & Molecular Biology Colorado State University Post-doctoral fellow positions in ubiquitin signaling and RNA virus replication biochemistry / structural biology The Peersen and Cohen laboratories at Colorado State University in Fort Collins are recruiting up to three post-doc positions for studies of macromolecular interactions and structure. The positions require a Ph.D. at time of hire with prior experience in protein biochemistry, molecular biology, or biophysical methods. The Peersen lab projects are focused on the structures of viral RNA-dependent RNA polymerases and the assembly of membrane anchored replication centers formed by single stranded RNA viruses. The projects will build on recent studies of viral elongation complexes (Gong & Peersen, PNAS 107:22505, Hobdey et al., J. Virology 84:8072) to further our understanding of polymerase function, replication fidelity, and higher order assemblies. Previous experience in X-ray crystallography, RNA biochemistry, membrane systems, or fluorescence methods would be advantageous. The Cohen laboratory position is to study mechanisms of signaling by polyubiquitin. Recent work defined the linkage-specific avidity mechanism for polyubiquitin binding (Sims & Cohen, Mol Cell 33:775-783; Sims et al., Nat. Struct. Mol. Biol. 16:883-889). Available projects include studies of polyubiquitin receptor proteins, development of linkage-specific polyubiquitin sensors, and investigation of the role of linkage-specificity in signaling by polyubiquitin in vivo. Candidates should have prior experience in protein biochemistry and molecular biology; familiarity with biophysical methods or mammalian cell culture is desirable. Applications should be received by August 5, 2011 for full consideration. Interested individuals should submit a CV, statement of research and career interests, and contact information for three references at http://www.natsci.colostate.edu/employment/bmbPdoc/ CSU is an EO/EA/AA employer. CSU conducts background checks on all final candidates.