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Dear Khan, There's a software package dedicated to the processing of resting state fMRI data (Rest, http://www.restfmri.net/forum/). The software is designed for human subjects, but I think it is feasible to replace the MNI template by a rat brain template, which may do the trick. Best regards Yun Lin -------------------------------------------------------------------------------- Physician, Master Candidate Department of Radiology, Southwest Hospital 3rd Military Medical University, Chongqing, China Phone: +86 150 2312 2673 MSN: [log in to unmask] Skype: lin.yun83 -----原始邮件----- From: hekmatyar Sent: Thursday, May 12, 2011 8:14 PM To: [log in to unmask] Subject: Re: [SPM] SPM resting state Hello SPM experts Is there anyway, I can do detrending and low pass filtering in the SPM for resting state functional connectivity measurements for my rat brain? Is there any procedure or method available in SPM? Please suggest me if you have come across. Thanks Regards Khan Hekmatyar PhD Bioimaging Research Center. University of Georgia, Athens, GA