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Dear SPM list

The generic advice in designing a DCM study seems to be to ensure that it is a 
2x2 factorial design with a driving sensory factor and a contextual factor (e.g. 
attention).

Is there a statistical/mechanistic basis for this advice in terms of the DCM 
analysis or is this advice just good practice for design efficiency and ensuring 
there is an interesting effect to explore. 


I'd be interested to understand more.

Thanks for any help you might provide.

Steven