thank you for your fast reply.

For example in your article "Brain atrophy analysis using single and multiple time point data" in the section

2.5 change analysis you talk about: bayesian framework and hidden markov random field.

Can you tell me please where and how do you applied them?

In the section 2.6 Percentage brain volume change quantification, you used A (actual brain area) and V (actual brain

volume), but how do you calculated them?

Thank you in advance.

2010/7/21 Stephen Smith <[log in to unmask]>

Hi - there isn't really any "maths" as such that is particularly interesting I think - SIENA is just a set of heuristic algorithms tuned for a specific application. Though you might be referring to a lower-level - for example the maths underneath BET or FAST - in which case those relevant papers have more information?Cheers.On 21 Jul 2010, at 10:56, Michele Placci wrote:Dear experts, can you tell me please if there is some publications

that talk about the MATHEMATHICS underlying the calculation of volumes, such as adopted by SIENA?

I read the article "Brain atrophy analysis using single and multiple time point data" Stephen M. Smith et al

but I'd like to know more details.

Can you help me please?

Thank you.

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Stephen M. Smith, Professor of Biomedical Engineering

Associate Director, Oxford University FMRIB Centre

FMRIB, JR Hospital, Headington, Oxford OX3 9DU, UK

+44 (0) 1865 222726 (fax 222717)

[log in to unmask] http://www.fmrib.ox.ac.uk/~steve

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