 |
 |
I have the following experimental paradigm: 1. patient and healthy control groups 2. each subject has two separate scanning sessions on 2 days 3. on each day subject has fMRI task followed by a)active substance OR b)placebo administration and repeat fMRI task I wanted to confirm proper design matrix construction to test the question of whether activation deltas (post - pre substance administration) differ among group A and B My thought is to use a variation of the Multi-Session & Multi-Subject (Repeated Measures - Three Level Analysis) scenario on the FEAT webpage but instead of running the initial fixed effects analysis on subject mean COPEs, run it instead on COPEs generated by a fixed effect analysis of before and after condition for each subject. Not sure if this is correct or how to design the matrix. Any advice would be much appreciated. Tal.