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Illuminated FSL masters, I am following a patient longitudinally, on a series of different tasks. Say the design is 1 subject performing 2 tasks each repeated 4 times. Would this set-up be correct? EV1: Overall subject mean [is this actually needed?] EV2: Task1 mean EV3: Task2 mean EVs4-7: Task1_T0 (reference group), Task1_T1, Task1_T2, Task1_T3 EVs8-11: Task2_T0 (reference group), Task2_T1, Task2_T2, Task2_T3 (visually..) Input File [Task1 T0] 1 1 0 0 0 0 0 0 0 0 0 [Task1 T1] 1 1 0 0 1 0 0 0 0 0 0 [Task1 T2] 1 1 0 0 0 1 0 0 0 0 0 [Task1 T3] 1 1 0 0 0 0 1 0 0 0 0 [Task2 T0] 1 0 1 0 0 0 0 0 0 0 0 [Task2 T1] 1 0 1 0 0 0 0 0 1 0 0 [Task2 T2] 1 0 1 0 0 0 0 0 0 1 0 [Task2 T3] 1 0 1 0 0 0 0 0 0 0 1 Contrasts & F-tests would be as follows: C1: 0 0 0 0 1 0 0 0 0 0 0 F1 (i.e. EV5) C2: 0 0 0 0 0 1 0 0 0 0 0 F1 (i.e. EV6 ) C3: 0 0 0 0 0 0 1 0 0 0 0 F1 (i.e. EV7) C4: 0 0 0 0 0 0 0 0 1 0 0 F2 (i.e. EV9) C5: 0 0 0 0 0 0 0 0 0 1 0 F2 (i.e. EV10) C6: 0 0 0 0 0 0 0 0 0 0 1 F2 (i.e. EV11) Contrasts & Ftests interpretations: F1 is the within subject effect for Test1 F2 is the within subject effect for Test2 Each contrasts is essentially like a Dunnett test (i.e. comparison of each repetition to its reference group). However, without the actual multiple comparisons correction of the Dunnett test (considering the number of voxels tested a few multiple comparisons are maybe not that big of an issue?!). Does this sound about right? cheers martin