You should be able to run the new segmentation on the skull-stripped data without any tweeks, providing the stripped off voxels are set to either 0 or NaN. Values of 0 or NaN in the image will be ignored. Best regards, -John On Thu, 2009-07-09 at 18:37 +0100, Ronald Pierson wrote: > I want to preprocess some scans for VBM using new segment and DARTEL. I > want to use both T1 and T2 scans, and they are currently brain-clipped. In > new segment can I run it with just the first three tissue classes, since there > are no non-brain tissues present? Any other suggestions, or is there a > tutorial/procedure manual available that would be useful for me to look at? > > Ronald Pierson > Chair of Imaging, PREDICT-HD > Manager, Research and Development > Department of Psychiatry, Carver College of Medicine > W-278 GH, 200 Hawkins Dr > Iowa City, IA 52242 > -- John Ashburner <[log in to unmask]>