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Hi, I am running TBSS-style analysis on MD maps for patients and controls. After all MD maps were registered to standard space, I run the movie loop to see how well the skeleton from the FA analysis fits each subject. I noticed that some of the subject have much higher (often twice the value of other subjects) MD values throughout the brain, compared to other subjects. These differences are seen in both controls and patient groups. The subjects that show high MD values to not seem to show any abnormalities in the FA values. What would be a possible explanation for these increased MD values? Sincerely, Anastasia