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Just out of curiosity, and to help guide my analysis, what makes more sense? 1) Run stats (i.e., GLM) in native space, then normalizing the resulting statistical image or 2) Running the statistics on normalized data? is the answer different for different analyses? what do you do? what is your justification? Thanks for any advice, Michael p.s. I have been in the habit of typically running stats on normalized data -- Research Associate Gazzaley Lab Department of Neurology University of California, San Francisco