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Dear all, after reading the post about DCM and 2x2 designs, I still have a question.... In my data I found an interaction reflected by 3 significnat activated areas (one in V3). In my DCM analysis I want to look for the modulation of theses three areas (at least of two of them), but I am not sure, what area should I use as driving input. One of my two main effects for different stimuli showed one area that overlaps at least in parts with one area activated in the interaction (V3). Should this area used as the driving input? Should I use always one area from the interaction contrast? Or should I use an area from the main effect??? Thank you very much boris -- Priv.- Doz. Dr. Boris Suchan Institute of Cognitive Neuroscience Department of Neuropsychology GAFO 05/613 Universitätsstrasse 150 44780 Bochum phone: + 49 234 3227575 mailto:[log in to unmask]