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hello: 
well, i actually found out that the images  have the following sizes:
512 x 512 x 20
i mean that the voxel size in the image is a lot diferent.
0.41 x 0.41 x 6.5

I have understood that the image has to be isotropic ( same size in x, y and
z ).

So, what can i do ?
Resampling the image?
take the images again?

Camilo