Hi SPMers, I've noticed that I have more luck with coregistration if I first bias correct and skull strip my T1 structural images with the VBM toolbox. See attached pictures for two examples (one is very noticeable, the other subtler). I've looked through the email archives and the spm5 manual and haven't seen any mention of it so far. Does anyone know why my coregistration might be off in the first place? Also, is this a valid workaround that has been tried before? Regards, Neil -- Neil R. Chatterjee Research Assistant Stanford Systems Neuroscience & Pain Lab 650-724-0522 [log in to unmask]