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Hi Qing > I'm calculating the lateralization index and I wonder how to realize: > (1) variable statisctical thresholds across subjects - for each > individual the selected threshold should correspond to a fixed number > of activated voxels in certain regions. > (2) mean activation of the 5% of voxels showing the highese level of > activation in certain ROI. > (3) % signal change analysis with a given threshold for inclusion > (i.e. only the voxels that exceed the given activation level are > included to calculate). I would recommend the excellent Marco Wilke LI toolbox - it does everything you want within the robust bootstrap framework ... Cyril