Hi Shaquanda, > As is often the case, I can find all sorts of theoretical information about how to do VBM (e.g. formulas, etc.) but I cannot find any examples or workshop data sets of how actually do to VBM statistics on using SPM? Sometimes finding out exactly ho to actually do things is hardest (partly because there are many different ways to do it :) Generally, what you do after you processed your images (which has become one hell of a lot easier in spm5, so I really recommend you use that version) you do a statistical comparison by entering your data into a second-level statistical model. For example, if you want to compare two groups (patients vs. controls) you could click on segment, select all subject Output files: unmodulated normalized GM run segment click on smooth, select all wc1*.img smoothing width, say, 12 x 12 x 12 mm run smooth click on second level statistical model select 2-sample-t-test select patients as one group, controls as the other run stats click on results, define your contrast (e.g., 1 -1 or so) correct for multiple comparisons (recommended unless you have VERY convincing arguments to the contrary) see group differences publish I admit that this is not the whole story and there may be some more bumps in the road but perhaps it gets you started. Also try the spm manual, it is very helpful to understand, for example, what options to choose during segmentation, or smoothing, or stats. Good luck :) Marko -- ===================================================================== Marko Wilke (Dr.med./M.D.) [log in to unmask] Universitäts-Kinderklinik University Children's Hospital Abt. III (Neuropädiatrie) Dept. III (Pediatric neurology) Hoppe-Seyler-Str. 1, D - 72076 Tübingen Tel.: (+49) 07071 29-83416 Fax: (+49) 07071 29-5473 =====================================================================