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Hello- I've had a problem crop up with FLIRT that I'm a bit confused by. In the study I'm running, 19 out of 20 subjects have been run perfectly fine through func2highres and highres2standard. However, for one subject, it has attempted to register hires2standard along the wrong directions. The axial is being registered to the saggital and vice versa. The coronal is being registered to the coronal, but the final solution is tipped to one side. I've checked all of the original DICOM info that I can think of, and all listings of patient orientation, slice acquisition/encoding direction, etc is all the same. The only difference is that the subject's head was tilted at a bit of an angle during scanning, but certainly not to the degree that the coronal is tipped in the FLIRT registration solution. Images are available at http://www.tc.umn.edu/~norb0062/BAD_highres2standard.jpg http://www.tc.umn.edu/~norb0062/GOOD_highres2standard.jpg Do you have any suggestions for manual intervention? Thanks in advance, -- Jim Porter TRiCAM Lab Coordinator Elliott Hall N437 612.624.3892 www.psych.umn.edu/research/tricam