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Does anyone have any experience (good or bad) with registering a DTI image to a T1 image? The images have different spatial resolutions, but are oriented the same way. I've been trying to do so, but the results are terrible. I've tried the following methods so far: 1) Registered full head DTI (b=0) with full head T1 => poorly registered because DTI image does not have enough contrast on the skull and skin, i.e. those areas are relatively dark in the DTI relative to the brain. In the T1, that's not the case. 2) Registered brain DTI (b=0) with brain T1 (brains were extracted using BET with some post BET editing) => poorly registered but have no idea why it should be Any suggestions or insights would be much appreciated. Hoang Tran Neurobehavioral Research, Inc. 201 Tamal Vista Blvd. Corte Madera, California 94925 415.927.6627 (Office) 415-924-2903 (Fax) [log in to unmask]