Dear collegue,
Yesterday, I was called to inspect an unusual protein
electrophoresis pattern. One lane of the Paragon gel showed an
broad albumin band, "bearding" towards the anode, no extra
(prealbumin) band to be seen. The patient turned out to have a
chronic renal failure: kreat 480 umol/L, urea 63 mmol/L, anion gap
24 mEq/L. Our present theory is that the broadening is caused by
association of albumin with charged molecules, retained by severe
renal failure. The patient did not get albumin therapy.
Is there anyone familiar with this phenomenon?
The only bearding band known to us thus far are the Dubliners, so
we propose the name albumin Dubliners.
Best wishes
Raymond Wulkan
Zuiderziekenhuis
Rotterdam
The Netherlands
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