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ALLSTAT  1999

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Subject:

SEMINAR at QMW, London

From:

Barbara Bogacka <[log in to unmask]>

Reply-To:

Barbara Bogacka <[log in to unmask]>

Date:

Tue, 26 Oct 1999 18:45:58 +0100

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (81 lines)

		   Queen Mary and  Westfield College
		    School of Mathematical Sciences
						       
		
			   STATISTICS SEMINAR

			4 November 1999, at 16.30

	"Applications of Multivariate Data Analysis and Modelling 
		    to Drug Discovery and Development"                                    

			           by
				PAUL NELSON
			   SmithKline Beecham


				  ABSTRACT
Ever increasing demands for information to answer questions about drug
products, process performance and the utility or potential of techniques in
drug discovery and development has led to the generation of a great many
measurements and the identification of a great many variables that can
simultaneously influence these measurements.

The problem that soon arises is one of locating the relevant information
among so much data and interpreting it easily and reliably. The information
of interest does not often lie in isolated variables, but in a combination
of several variables.

The solution is multivariate data analysis by projection methods such as
Principal Components Analysis (PCA) and Partial Least Squares (PLS). By
analysing all measurements simultaneously, multivariate projection methods
utilise correlations between variables to efficiently reduce the high
dimensional coordinate system to one comprising only a few relevant axes.
The information can then be displayed in simple graphs for easy but
comprehensive interpretation.

Applications of multivariate projection methods to pharmaceutical problems
will be given to illustrate how they can be used to uncover
structure-activity relations, patterns, oultiers, influential variables,
groupings and separations that would not have been discerned if the
measurements were analysed one-by-one.

			   
			ALL ARE WELCOME

The seminar takes place in the Mathematics Seminar Room (103)
on Level 1, Mathematics Building, Mile End Road,
Queen Mary and Westfield College.

Tea and coffee are available in the Mathematics Common Room (102) 
from 15.00.

The nearest underground station is Stepney Green. 
Turn left at the exit and walk 400 yards.


For more information ask:

Barbara Bogacka
School of Mathematical Sciences
Queen Mary and Westfield College
Mile End Road
London E1 4NS

Tel: 020 7882 5497
e-mail: [log in to unmask]
--------------------------------------------- 

The seminar information is kept on:

http://www.maths.qmw.ac.uk/~rab/seminars.html








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