ANNOUNCE CRM VERSION 1.0
'crm' version 1.0 is the first regular release of a menu-driven
computer program which implements the Continual Reassessment Method
(CRM) for dose-finding in phase I clinical trials. The code is
designed for use by physicians, research nurses and statisticians. It
provides a means to log in patients as they are accrued to the trial,
to record their outcomes from treatment ("toxicity" or "no toxicity"),
and it selects doses for successive cohorts of patients based on the
current data using the Bayesian method underlying the CRM.
The CRM was originally proposed by O'Quigley, Pepe and Fisher in 1990
in the paper cited below. The documentation accompanying the package
also contains a fairly complete bibliography.
O'Quigley, J., Pepe, M. Fisher, L. (1990) Continual reassessment
method: a practical design for phase I clinical trials in
cancer. Biometrics 46, 33-48.
WHERE TO GET IT
'crm' is furnished as Win32 PC and Power Macintosh executables, and as
source code written partly in standard Fortran 90 and partly in
standard Fortran 77. Readers with Internet access and a browser might
note the following web site addresses:
Available Software:
http://odin.mdacc.tmc.edu/anonftp/
University of Texas M. D. Anderson Cancer Center Home Page:
http://utmdacc.mdacc.tmc.edu/
Department of Biomathematics Home Page:
http://odin.mdacc.tmc.edu/
Our code can also be obtained by anonymous ftp to odin.mdacc.tmc.edu.
The code is also archived at many other sites (at their option). Use
your favorite search engine to find one close to you.
Software written by members of our section is freely available to
anyone. Reposting on other archives is encouraged.
John J. Venier [log in to unmask]
Barry W. Brown [log in to unmask]
Peter F. Thall [log in to unmask]
The University of Texas M. D. Anderson Cancer Center
Department of Biomathematics, Box 237
1515 Holcombe Boulevard
Houston, TX 77030 (USA)
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