Dear collegue,
maybe this is of help:
Brackett and Cohen
NEJM 1965;272;6
CO2 titration curve of normal man. Effects of increasing degrees of
acute hypercapnia on acid base equilibrium.
Best regards
Raymond Wulkan
Rotterdam
Organization: Royal Manchester Children's Hospital
Date sent: Wed, 17 Nov 1999 22:41:29 +0000
Priority: normal
Subject: Re: Haemoglobin and pCO2
From: "Dr G. M. Addison" <[log in to unmask]>
To: Les Culank <[log in to unmask]>
Copies to: [log in to unmask]
Send reply to: "Dr G. M. Addison" <[log in to unmask]>
Thanks Les
I think, I know, the haemoglobin is genuine despite the wrong unit
in my original message (24g/100ml NOT /L.) It has been measured
on several occasions and in different labs. We could try several
capillary collections to check the blood gas results and even do
the other sophisticated things you suggest if we could persuade
her into hospital but it is difficult just to get her to outpatients.
However, I will pass your suggestions on to her consultant.
What interests me is that the findings in her arterial blood gas
suggest acute changes as there was no metabolic compensation.
I did not believe you could get the high pCO2 by breath holding and
wondered if the results were aretefactual due to the extraordinarily
high Hb. My readings of the literature were not of much help so I
thought of the wide brotherhood of clinical biochemists out there
who had the time to read their email and even reply. Surely they
would have the answer!!
Mike
Dr G Michael Addison
Department of Clinical Biochemistry
Royal Manchester Children's Hospital
Pendlebury
Manchester M27 4HA
Tel 0161-727-2250 or 0161-220-5342
Fax 0161-727-2249
Email [log in to unmask]
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