We have been working up Abbott AxSYM Troponin I assay for introduction into
routine service. Presently we do Vitros total CK with AxSYM CK-MB mass in
selected cases by special request. We have been doing TnI on these CK-MBs
in parallel. Findings reinforce the paper in Feb 99 Clinical Chemistry but
we came across this case which has puzzeled us. Does anyone have any
experience to throw light on the situation?
A 93 year old lady admitted via A&E (ER for colleagues in US) with history
of "fall, collapsed, low temperatue ?cause".
Admission: CK 1372 iu/L (Ref Range < 135)
CK-MB 131 ug/L ( < 7.0 )
TnI 0.2 ug/L
9 hours later: CK 794
CK-MB 68.4
TnI 0.2
Trop T 0.02 ug/L ( < 0.10 )
Non-specific ECG changes were noted.
35 hours later: CK 428
CK-MB 22.9
TnI 0.1
Do the AxSYM CK-MB or TnI assay suffer HMMA effects? Results of CK
isoenzymes by electrophoresis are awaited.
Thanks
Geoff Lester
Chemical Pathology Department
Frenchay Hospital
BRISTOL UK.
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