I think that a big problem with measuring myoglobin in urine is that most
current methods (including our own) are simply not sensitive enough - a
relatively large amount of myoglobin has to be present before it can be
detected reliably. CK, though not as specific, is far more sensitive to
rhabdomyolysis. I have never seen a positive urine myoglobin without a very
significantly elevated CK (>>1000 IU/L); and we have had a considerable
number of cases where rhabdomyolyis was present (eg see my Case for Comment
No 9: hypothyroidism, hypothermia, and rhabdomyolysis) but we failed to
detect urine myoglobin.
Gordon Challand
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> From: Samuel Vasikaran <[log in to unmask]>
> To: [log in to unmask]
> Subject: Re: Rhabdomyolysis
> Date: 04 July 1998 03:50
>
> Are there situations where myoglobinuria can be present without a
> significantly (above a certain cut-off) raised CK?
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