This is a bit puzzling. I’m wondering if it has to do with the spectrum “scale” (as set in the Experiment —> Spectra dialog in the Spectra tab). In Analysis 2.4.1 the calculation of the standard deviation via the ctrl drag was not multiplying the result by the scale, which it should have been. This was fixed in Analysis 2.4.2 at some point around 31 March 2017. Do you have the 2.4.2 updates (at least some point after that date)? But if this is the issue then you would observe what you say only if the scale was < 1, so if it’s 1 (the default) or > 1 then it should be another issue.
Wayne
> On 17 Apr 2019, at 08:45, Beate Bersch <[log in to unmask]> wrote:
>
> Dear all
> I am coming back to the question asked by Micael some times ago.
> I noticed exactly the same problem: the estimated noise (ctrl dragging a box in an empty spectral region) gives values that are enormous compared to peak intensities fitted in the same spectrum (in my spectra, I have a very decent S/N, beautiful protein, 0.6 mM at least ....).
> I suppose that there is some factor between the two different values ...
> I am (still) using ccpnmr 2.4.2
>
> Thank you
>
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