We offer a fully funded PhD opportunity in the Department of Mathematics
and Statistics at Lancaster University commencing in October 2019. The PhD
will develop clinical trial designs for establishing treatment duration in
infectious diseases (further details below) and be supervised by Prof
Thomas Jaki (Lancaster University), Dr Pavel Mozgunov (Lancaster Univsity)
and Prof Gerry Davies (University of Liverpool).
This 3 year studentship covers tuition fees, research support costs, and a
stipend at UKRI standard rates (£14,999 pa for 2019/20) and is open to UK
and EU candidates.
To apply please send your cover letter and CV to Thomas Jaki (
[log in to unmask]) no later then 3rd March 2019.
Synopsis:
In many infectious diseases such as Tuberculosis (TB) or Hepatitis B (HBV)
the period of treatment with current standard regimes is lengthy. In
Tuberculosis and HBV, for example, treatment periods of 6 and 12 months,
respectively, are typical. Long treatment periods results in a large burden
on the patients, potentially high costs and increased risk of
non-compliance to treatment. Novel treatments or combinations of treatments
in these areas, however, offer the opportunity for both higher efficacy and
shorter treatment periods.
In this project we will investigate novel clinical trial designs that, in
an exploratory stage, identify the shortest, promising treatment duration
followed seamlessly by a confirmatory stage to test the effect of the
treatment under this treatment duration. We will explore (Bayesian)
adaptive methods for this purpose that identify the best treatment duration
while maintaining control of the overall errors in the study.
--
Thomas Jaki, PhD
Professor of Statistics
Medical and Pharmaceutical Statistics Research Unit
Department of Mathematics and Statistics
Lancaster University
Lancaster LA1 4YF
United Kingdom
(+44) 01524 592318
www.mps-research.com
http://www.lancaster.ac.uk/maths/about-us/people/thomas-jaki
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