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CCP4BB  February 2019

CCP4BB February 2019

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Subject:

Postdoctoral position in structural biology of influenza virus transcription Cusack group, EMBL Grenoble

From:

Stephen Cusack <[log in to unmask]>

Reply-To:

Stephen Cusack <[log in to unmask]>

Date:

Tue, 26 Feb 2019 13:53:52 +0100

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text/plain

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Dear All,

     We are looking for a highly motivated and ambitious individual to 
progress our understanding of the mechanism of transcription by 
influenza virus RNA-dependent RNA polymerase. The work is in the frame 
of the ANR-funded FluTranscript project that brings together the 
complementary expertise of the groups of Stephen Cusack (EMBL Grenoble, 
project coordinator) and Nadia Naffakh (Institut Pasteur) in structural 
biology and molecular virology, respectively. The project follows on 
from a recent joint publication (Structural basis of an essential 
interaction between influenza polymerase and Pol II CTD. Lukarska et al, 
Nature 2017) and aims to reconstitute and determine the structure of 
functional transcription complexes. A secondary goal is to use the 
acquired structural information to develop new approaches to 
anti-influenza drug development.

     The Cusack group uses X-ray crystallography and cryo 
electron-microscopy to study the structural biology of protein-RNA 
complexes involved in RNA virus replication, innate immunity and 
cellular RNA metabolism. Group website: 
https://www.embl.fr/research/unit/cusack/index.html

     The successful candidate should have a PhD in Molecular Biology or 
related field and a strong background and interest in biochemistry and 
structural biology.
We are looking for a creative and ambitious person with good 
communication skills and keen to work on a challenging project.

     Experience in insect cell expression systems, reconstitution of 
protein-RNA complexes, X-ray crystallography or cryo-electron microscopy 
would be particularly beneficial.

     EMBL is one of the world’s leading research organizations in the 
life sciences. The Headquarters Laboratory is located in Heidelberg, 
with additional sites in Barcelona, Grenoble, Hamburg, Hinxton, and Rome.

     EMBL Grenoble has excellent access to state-of-the-art structural 
biology technologies with the in house EM facility being equipped with a 
T12 microscope and 200kV Glacios/Falcon III . Additionally, we have 
access to the Titan Krios at the adjacent ESRF as well as those in EMBL 
Heidelberg. Other facilities on the Grenoble Campus include the ESRF 
synchrotron X-ray beamlines, neutron scattering at the ILL, high-field 
NMR at the IBS as well as high-throughput crystallization platform, 
mammalian and insect cell facilities, biophysical platform and confocal 
microscopy.

You can find out more about this vacancy at:
https://www.embl.fr/jobs/searchjobs/index.php?ref=GR00133

or by contacting Stephen Cusack: [log in to unmask]

Please apply online through www.embl.org/

Stephen Cusack

-- 

**********************************************************************
Dr. Stephen Cusack, FRS
Head of Grenoble Outstation of the European Molecular Biology Laboratory (EMBL)
Group leader in structural biology of protein-RNA complexes and viral proteins
**********************************************************************

Email:	[log in to unmask]				
Website: http://www.embl.fr			
Tel:	(33) 4 76 20 7238    Secretary (33) 4 76 20 7123				
Fax:    (33) 4 76 20 7199					
Postal address:   EMBL Grenoble Outstation, 71 Avenue des Martyrs, CS 90181, 38042 Grenoble Cedex 9, France
Delivery address: EMBL Grenoble Outstation, Polygone Scientifique, 71 Avenue des Martyrs, 38000 Grenoble, France
**********************************************************************

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