Research Fellow in Mathematics and Computational Statistics of Self Organisation in Cell Division (88190-058)
Warwick Mathematics Institute, UK. Job ref 1726416.
Fixed term contract for 4 years.
Start date ideally during summer 2018.
Closing date 4th June 2018. Interviews will take place in early June.
Applications are invited for a postdoctoral research fellow to work on the modelling and statistical inference of chromosome self-organisation during cell division. The project will develop and implement Bayesian algorithms to fit (infer) 3D mechanics inspired models to tracked chromosome trajectories generated from high-resolution experimental imaging time-series data (generated from human cells). The models are stochastic differential equations incorporating multiple ‘movement states’ (a hidden Markov model, HMM); the number of states is unknown so a hierarchical Dirichlet process will be used. The aim is to achieve through data driven model development an unprecedented level of understanding of chromosome organisation in cell division, and thus an understanding of how it goes wrong in diseases such as cancer. The project is a collaboration between Burroughs’ theory group and an experimental lab in the Warwick Medical School.
The ideal candidate will have a relevant PhD, e.g. in statistics/mathematics/physics/machine learning, and have a strong background in stochastic modelling and/or computational statistics, e.g. Markov chain Monte Carlo (MCMC), particle filters/sequential Monte Carlo. A background in HMM inference using MCMC algorithms will be beneficial, whilst an ability to programme in MATLAB, C++ an advantage. A background in biology is not required.
Applications can be made through the advert website http://www.jobs.ac.uk/job/BJP372/research-fellow-in-mathematics-and-computational-statistics-of-self-organisation-in-cell-division-88190-058/ and should include 1) a letter of application outlining previous research experience/significant results and why you are interested in the post, 2) a CV, 3) a list of publications, and 4) links to a small selection of reprints/preprints/publications from your PhD/latest research post as appropriate. Scientific queries about the project can be made to Prof Burroughs, [log in to unmask], or see his website https://warwick.ac.uk/fac/cross_fac/zeeman_institute/staffv2/burroughs/.
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