Dr Ying Chen will be giving a talk on "Summarising dosage of prescribed drugs: an example using opioids" as part of our Biostatistics seminar series at Research Institute for Primary Care & Health Sciences, Keele University.
Monday 26th March 10-11:30am in Dinwoodie lecture theatre, Primary Care Sciences, David Weatherall building, Keele University ST5 5BG.
Abstract: The Clinical Practice Research Datalink (CPRD), an anonymised database of routinely recorded information from UK general practices, contains prescription details for each consultation. It can be used to identify morbidity, describe prescribing trends, investigate drug safety, etc. Taking opioids as an example, method used to summary the dosage of prescription in order to assess its association with risk of adverse events will be described.
The daily morphine equivalent dose (MED) for each opioid medication was obtained by using a conversion factor for morphine equivalence. The MED for a single prescription was calculated by multiplying the quantity of medication prescribed by the conversion factor. Total MED in a long-term opioid episode was calculated by adding the MEDs for each prescription dispensed during the episode. Average daily MED prescribed was the total MED for a long-term opioid episode divided by episode duration in days. In those participants, where an outcome of interest occurred within a long-term opioid episode, average MED was calculated only for the period before that outcome occurred, in order to minimise the influence from a potential prescribing change due to an outcome event.
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