Dear SPM experts,
I am working on a DCM analysis (using DCM12) involving two regions and am interested in being able to make inferences at the parameter level. Specifically, I found a winning model with BMS that shows that my experimental input modulates bi-directional coupling between my two regions, and I would like to see if the coupling positively or negatively modulated.
Although I get interesting results from applying BMA to this data, I would like to make sure my interpretation is correct. I am a bit concerned about the reliability of parameter level inference, given the 2015 NeuroImage paper from Fraessle etal suggests that parameter estimates under DCM10 and 12 may be less reliable than older versions. In my case, which is within subjects, so no between-group tests, I find that my manipulation results in positive modulation of one connection, and negative modulation in the other correction. Can I then say that the coupling is increased in one case and suppressed in the other? Or are the parameter estimates not reliable enough for this type of inference?
Thanks in advance!
Best regards,
James Trujillo
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