I have used LST toolbox on SPM (LPA algorithm) to do Flair segmentation to hyperintensity regions many times. The issue is that for just one of my subjects which Fair data seems OK, the results of LPA does not make sense. Indeed, Flair map as the result of Flair segementation is so exaggerated by enlarged hyperintensity areas. I do not have any idea why this happened to this data and how I can fix that to a real segmented result. Here, I provided two screen shots of original Flair and Flair map (result of segmentation) superimposed on Flair data, you can see and compare how hyprintensity areas are in different size is these two images. Any help to solve my problem is appreciated and please let me know if you need some more information. Thank you so much.