Dear Anderson,
I enjoyed studying this great manuscript!
Thank you very much for the effort and time spent on this study.
I highly appreciate if you can answer my questions regarding the relationship between cortical thickness and gray matter volume.
I have two groups of subjects (60 patients and 20 controls). I ran VBM on T1 images to check the difference in gray matter volume. then I ran surface based analysis to study volume on surface and cortical thickness. VBM and surface based revealed no difference in gray matter volume. Surface based approach revealed difference in cortical thickness.
Given that the: (cortical thickness = gray matter volume (GMV) X area) that means GMV and thickness are related to each other and the change between these parameters can affect each other.
My question is how can we explain reduce cortical thickness and normal gray matter volume. Is this possible?
I highly appreciate your input;
John
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