Dear experts,
we are currently trying to do a repeated measure design and wanted to check in patients whether questionnaire score changes are associated with DTI structure changes.
We therefore created con images of skeletonized FA images (created via FSL tbss pipeline), by substracting prae FA images from post images with the fslmaths tbss_post -sub tbss_prae tbss_con_image command. We then correlated these con images with the difference in questionnaire scores (questionnaire_prae - questionnare_post).
Is this a valid approach to check whether changes in symptomatology are associated with fibre structure changes over time? If not, what would be a better way to solve this problem?
Thanks a lot in advance!
Jonathan
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