Dear Gayane,
You pose an interesting question. Indeed many papers that studied amyloid PET mention the use of an amyloid template, however I haven't found a paper explicitly mentioning how the template was built and its validation. (maybe I didn't look well enough, I didn't spend a lot of time looking... but still even the references are generally not relevant). Anyway, try looking at the ADNI collaboration, they used a template on a number of papers, therefore they should have it somewhere, hopefully available.
And I believe that, if an amyloid template can ever work, its validation is fundamental! Amyloid images are characterized by extremely different spatial features between people with no burden and people with a high burden. Those without have a very well defined White matter structure, those with have almost no discernible anatomical features. Therefore I would think that even normalizing "positive" images to a positive template might be problematic, as anatomical features are generally lacking. If you factor into this that positive and negative images are *very* different, I'd say that there is a high chance of such an approach not to work in general and there is a high risk of introducing some serious bias between positive and negative groups.
Regards,
Luca
________________________________________
Da: SPM (Statistical Parametric Mapping) <[log in to unmask]> per conto di Gayane Aghakhanyan <[log in to unmask]>
Inviato: domenica 5 giugno 2016 09.37.42
A: [log in to unmask]
Oggetto: [SPM] amyloid PET template
Dear SPM community,
I have limited amyloid PET data of two different groups of subjects, unfortunately, without corresponding 3D T1 MRI data. Nonetheless, I'd like to apply voxel-wise between group comparison of amyloid uptake by using an amyloid PET template. Could some suggest me any useful sources where I can find/ask/request an amyloid PET template to be used only for the research proposes?
Thank you beforehand,
Gayane Aghakhanyan, MD, PhD
Resident Physician
University of Pisa, Department of Translational
Research and of New Surgical and Medical Technology
Tel: +393277013870
email: [log in to unmask]
Rispetta l’ambiente: non stampare questa mail se non è necessario.
Respect the environment: if it's not necessary, don't print this mail.
IL TUO 5XMILLE AL SAN RAFFAELE DI MILANO
Devolvi il tuo 5 per mille all’Ospedale San Raffaele: perché al centro della Ricerca ci sei TU. CODICE FISCALE: 07636600962, nel riquadro RICERCA SANITARIA. Non c’è cura, senza ricerca. Non c’è ricerca, senza il tuo 5xmille. Scopri come su http://www.5xmille.org
[http://www.5xmille.org/img/731x129.jpg]
|