Postdoctoral Fellow (Structural Biology Algorithm Developer) - 82354
Organization: MB-Molecular Biophys & Integ Bio
Berkeley Lab is Bringing Science Solutions to the World, and YOU can be a part of it!
In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with "excellence." That's why we hire the best - whether in research, finance or other operations. This is a great opportunity to bring your top-notch skills to bear in support of world-class scientific research that addresses national and global challenges!
Position Summary:
Berkeley Lab's Molecular Biophysics and Integrated Bioimaging Division is looking for a Computational Biologist Postdoctoral Fellow to work in the Sauter group. We are seeking an algorithm developer for the increasingly complex analysis of large diffraction datasets in structural biology. We developed key software (DIALS and cctbx.xfel) for processing crystallography data at synchrotron and X-ray free-electron laser (XFEL) sources, and are currently using XFEL crystallography and spectroscopy to investigate the photosynthetic mechanism of water splitting, to probe other metalloenzyme reactions, and to test whether diffuse scattering can reveal correlated atomic motions in crystals. Many problems remain to be solved, including the details of how to optimally merge datasets from thousands of crystals. Past work has been highlighted in several high-impact publications listed HERE.
Specific Responsibilities:
• Expertise in ray tracing to test underlying physical models of the diffraction, Bayesian approaches for refining model parameters, macromolecular modeling and refinement, neural networks for interpreting image features, as well as signal processing and denoising methods.
• Implement algorithms within the DIALS framework for primary data reduction of synchrotron and XFEL diffraction.
• Fundamentally analyze the experimental geometry and physics to develop new insights and algorithms, especially to improve the accuracy of anomalous dispersion data, enable the analysis of overlapping Bragg lattices, develop physical models of protein crystal disorder, and interpret diffuse scattering.
• Support new experimental configurations including new detectors and light sources.
• Work with beamline scientists worldwide to customize and validate software at different locations.
• Collaborate with users to gain an understanding of how the software is deployed in practice.
• Elicit and anticipate user needs & respond to user feedback.
• Take a team approach for integrating the new code into existing software systems, including various graphical displays and beamline systems.
• Publish frequently and participate in conferences.
Required Qualifications:
• Ph.D. in Computational Biology, Computer Science, Biophysics, Applied Mathematics and/or related areas.
• Experience in crystallography as well as those from more general bioimaging backgrounds.
• Comprehensive understanding of diffraction physics and numerical approaches to X-ray crystallography, with a demonstrated ability to analyze specific scenarios and develop an algorithmic strategy.
• Demonstrated ability to organize a many-faceted project with only broad supervision, while running appropriate controls to validate the correct results.
• Strong written and verbal communication skills.
• Ability to write clear computer documentation including Web-based documentation.
• Experience with forefront approaches such as GPU computing or specialized hardware like neuromorphic chips.
• Ability to deliver product in a timely fashion.
• Ability to travel to light source facilities for data collection trips.
• Must be available to work: Monday - Friday: 9 am - 5 pm
Additional Desired Qualifications:
• Software languages: C++, Python, MATLAB
• Operating systems: Linux, Macintosh
• Ability to incorporate existing software libraries into new processes
• Development of graphical user interfaces
• Basic understanding of database systems & image formats
• Strong mathematical, data processing intuition, and a track record of bringing new ideas and tools to fruition, as evidenced through written publication and clear presentation.
The posting shall remain open until the position is filled, however for full consideration, please apply by close of business on May 20, 2016.
Notes: Berkeley Lab understands the postdoctoral experience in a research environment is unique. We are committed to the growth and development of early career researchers in pursuit of becoming next generation scientists and engineers. Read about the excellent postdoctoral benefits at Berkeley Lab.
This is a 1 year term appointment with the possibility of renewal for up to 5 years based upon satisfactory job performance, continuing availability of funds, and ongoing operational needs. You must have less than 2 of years paid postdoctoral experience. Salary for Postdoctoral positions depends on years of experience post-degree.
This position requires completion of a background check.
How To Apply
Apply directly online at http://50.73.55.13/counter.php?id=68059 and follow the on-line instructions to complete the application process.
Berkeley Lab addresses the world’s most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab’s scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy’s Office of Science.
Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4 (http://www.dol.gov/ofccp/pdf/EO13665_PrescribedNondiscriminationPostingLanguage_JRFQA508c.pdf). Click here (http://www.dol.gov/ofccp/regs/compliance/posters/pdf/eeopost.pdf) to view the poster: "Equal Employment Opportunity is the Law".
|
