Dear ccp4bb,
Please see the advertisement below from Steve Almo.
Kind regards,
Jeff Bonanno
We are looking to recruit an individual who will assume the role of PROGRAM LEADER for a large-scale program focused on enzyme functional annotation. Primary responsibility will be the oversight of high-throughput bacterial expression and protein production platform to support the needs of enzymologists, structural biologists and informaticists. At least three years of experience with high-throughput approaches and automation, as applied to protein production and structural biology, is strictly required.
This position will be associated with the Albert Einstein Macromolecular Therapeutics Development Facility, which supports a wide range of platforms for protein expression (bacterial and eukaryotic), ligand discovery, receptor-ligand deorphaning and the development of new immunotherapies. The successful candidate will oversee the day-to-day activities of cloning, prokaryotic expression and purification, as well as ligand discovery, and will be expected to interact effectively with a multi-institutional team possessing expertise in informatics, structural biology, computational chemistry, enzymology, genetics and metabolomics. Please see references below for an introduction to the program.
This position requires outstanding management, organizational and leadership skills, and provides considerable opportunities for scientific and technology development. The Protein Production Core exploits extensive automation and an active program focused on the development of novel protein expression/purification/functional annotation strategies. Candidates should contact:
Steven Almo, Ph.D.
Albert Einstein College of Medicine
steve<dot>almo<at>einstein<dot>yu<dot>edu
"Experimental strategies for functional annotation and metabolism discovery: targeted screening of solute binding proteins and unbiased panning of metabolomes." Biochemistry. 2015 Jan 27;54(3):909-31.
"Prediction and characterization of enzymatic activities guided by sequence similarity and genome neighborhood networks." Elife, 2014 Jun 30;3.
"Discovery of new enzymes and metabolic pathways by using structure and genome context." Nature, 2013 Oct 31;502(7473):698-702.
"Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily." Proc Natl Acad Sci U S A 2012 Mar 13;109(11):4122-7.
"Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily." Proc Natl Acad Sci U S A 2013 Mar 26;110(13):E1196-202.
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