Apologies for any cross posting.
MRC DTP Precision Medicine funded PhD Scholarship
Open to UK/EU students only (EU students must be able to demonstrate
that they have resided in the UK for three years prior to commencing
Fully funded with Research Council's stipend (£14,296 for 2016-17)
"Investigating Individual Specific Effects in Omics Datasets"
New omics technologies have yielded vast data sets on the degree of
molecular variation in individuals with a wide range of inherited and
acquired disorders. Analysis of these datasets under the classic
case-control paradigm has revealed key differences between those with
and without disease, but many of the claims made of these technologies
remain unfulfilled. Limitations in the analysis of datasets play their
part. There is also considerable symptomatic and molecular variation
within any group of patients that the case-control paradigm
oversimplifies. Recently, we have found evidence of a previously
unaccounted source of individual-specific variability in microarray data
from myotonic dystrophy patients. This project aims to develop
analytical methods that account for individual specific effects in the
analysis of omic datasets and investigate their significance and genetic
basis across a range of studies and disorders. The student will develop
these methods using generalized linear models and Bayesian analyses and
apply them to in-house and publicly available data sets.
The project will be based in the Institute of Cardiovascular and Medical
Sciences at the University of Glasgow with the primary supervisor, Dr
John McClure, and will also be supervised by Prof Darren Monckton
(Institute of Molecular, Cell and Systems Biology) and Dr Simon Rogers
(School of Computing Science). Glasgow is a vibrant and forward-looking
city, situated close to some of Europe's most beautiful countryside.
Applicants should have obtained, or expect to obtain a 2:1 or 1st Class
Honours (or equivalent) Bachelors or Masters degree, preferably in a
quantitative discipline (e.g. statistics, genetics, bioinformatics,
applied mathematics or computing). The PhD studentship will be available
for 4 years for those with a high BSc (Hons) and for 3.5 years for
students already with a relevant masters degree. Training with a suite
of bespoke precision medicine courses will be informed by individual
assessment of training needs.
For more information on this project, contact
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The deadline for initial applications is 4th April 2016.
More information on eligibility and how to formally apply for this
project can be found here:
John D. McClure, Ph.D.
Lecturer in Statistics
Institute of Cardiovascular and Medical Sciences
University of Glasgow
BHF GCRC, 126 University Place, Glasgow, G12 8TA
Tel.: 0141 330 2911
e-mail: [log in to unmask]
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