Hi Anderson,
I am so sorry for having bothered you. I've found the response in others sheets of your file. It's all that I want, but I cannot make it just with one design?
Thanks a lots,
Kim
On Fri, 13 Nov 2015 08:58:05 +0000, Kim TRAN <[log in to unmask]> wrote:
>Hi Anderson,
>
>Thank you very much for your reply. The contrasts C1 and C2 in your attached file are the differences (t1-t2) for each group? Because I want to run a one side t-test, could I add these 2 more contrasts for a complete approach:
>C5: -1 0 0 0 0 ... (t2-t1 in group 1)
>C6: 0 -1 0 0 0 ... (t2-t1 in group 2)
>
>Might they change the interpretation of C3 and C4?
>
>Thanks a lots,
>
>Kim
>
>
>On Fri, 13 Nov 2015 07:46:47 +0000, Anderson M. Winkler <[log in to unmask]> wrote:
>
>>Hi Kim,
>>
>>Design is fine, but the contrasts need to be changed. Please, delete all of
>>them and instead use:
>>
>>C1: 1 -1 0 0 0 0 ....
>>C2: -1 1 0 0 0 0 ....
>>
>>These will test the effect of the treatment, and can be used in FEAT,
>>randomise, or PALM.
>>
>>However, it seems you also want to compare groups in the 1st and 2nd scans,
>>is this correct? If yes, please see at this link
>><https://dl.dropboxusercontent.com/u/2785709/outbox/mailinglist/design_kimtran.ods>
>>the relevant designs. You'd need to use PALM, in which case you can also
>>correct across all of them in the same run (option -corrcon). Include the
>>options -whole and -within (both) if you take this route.
>>
>>All the best,
>>
>>Anderson
>>
>>
>>
>>On 12 November 2015 at 16:24, Kim TRAN <[log in to unmask]> wrote:
>>
>>> Dear FSL experts,
>>>
>>> I have 8 subjects, each scanned 2 times at 2 times point. The fisrt 5
>>> subjects are in drug group, and another 3 are in placebo group. I want to
>>> compare results of those 2 groups. Are the design and contrasts below
>>> correct?
>>>
>>> EB EV1 EV2 EV3 EV4 EV5 EV6 EV7 EV8
>>> EV9 EV10
>>> 1 1 0 1 0 0 0 0 0 0
>>> 0
>>> 1 -1 0 1 0 0 0 0 0 0
>>> 0
>>> 2 1 0 0 1 0 0 0 0 0
>>> 0
>>> 2 -1 0 0 1 0 0 0 0 0
>>> 0
>>> 3 1 0 0 0 1 0 0 0 0
>>> 0
>>> 3 -1 0 0 0 1 0 0 0 0
>>> 0
>>> 4 1 0 0 0 0 1 0 0 0
>>> 0
>>> 4 -1 0 0 0 0 1 0 0 0
>>> 0
>>> 5 1 0 0 0 0 0 1 0 0
>>> 0
>>> 5 -1 0 0 0 0 0 1 0 0
>>> 0
>>> 6 0 1 0 0 0 0 0 1 0
>>> 0
>>> 6 0 -1 0 0 0 0 0 1 0
>>> 0
>>> 7 0 1 0 0 0 0 0 0 1
>>> 0
>>> 7 0 -1 0 0 0 0 0 0 1
>>> 0
>>> 8 0 1 0 0 0 0 0 0 0
>>> 1
>>> 8 0 -1 0 0 0 0 0 0 0
>>> 1
>>>
>>> Contrast:
>>> mean G1, 1st scan 5 0 1 1 1 1 1
>>> 0 0 0
>>> mean G1, 2nd scan -5 0 1 1 1 1 1
>>> 0 0 0
>>> mean G2, 1st scan 0 3 0 0 0 0 0
>>> 1 1 1
>>> mean G2, 2nd scan 0 -3 0 0 0 0 0
>>> 1 1 1
>>> G1 > G2, 1st scan 5 -3 1 1 1 1 1
>>> -1 -1 -1
>>> G1 > G2, 2nd scan -5 3 1 1 1 1 1
>>> -1 -1 -1
>>>
>>> Any help you can provide will be greatly appreciated.
>>> Best regard,
>>> Kim
>>>
>>
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