JiscMail Logo
Email discussion lists for the UK Education and Research communities

Help for SPM Archives


SPM Archives

SPM Archives


SPM@JISCMAIL.AC.UK


View:

Message:

[

First

|

Previous

|

Next

|

Last

]

By Topic:

[

First

|

Previous

|

Next

|

Last

]

By Author:

[

First

|

Previous

|

Next

|

Last

]

Font:

Monospaced Font

LISTSERV Archives

LISTSERV Archives

SPM Home

SPM Home

SPM  September 2015

SPM September 2015

Options

Subscribe or Unsubscribe

Subscribe or Unsubscribe

Log In

Log In

Get Password

Get Password

Subject:

Re: voxelwise correction with additional cluster correction?

From:

"H. Nebl" <[log in to unmask]>

Reply-To:

H. Nebl

Date:

Tue, 22 Sep 2015 15:46:15 +0100

Content-Type:

text/plain

Parts/Attachments:

Parts/Attachments

text/plain (12 lines)

Dear Horatio,

First of all, note that voxel-wise FDR correction is somewhat disputed, which is also the reason why it has been replaced by topological FDR on peak or cluster level in SPM (see http://dx.doi.org/10.1016/j.neuroimage.2008.05.021 and http://dx.doi.org/10.1016%2Fj.neuroimage.2009.10.090 ), although the "old" voxel FDR can still be enabled by modifiy spm_defaults. Voxel FDR is NOT topological FDR on peak level, which is often confused.

Leaving this aside, as you already try to account for multiple testing with the (corrected) voxel-wise FDR there's no need to go with another "statistical" threshold on cluster level. Your approach would be especially uncommon as you rely on uncorrected cluster p values, which are really hardly ever used. Thus there's no benefit, rather it makes it a little obscure as one would start to wonder what you were trying to do.

Just to make sure, if you go with a correction on voxel level then any of the remaining voxels is sig., be it 1 voxel or 100,000. In fact we would have to interpret every single voxel separately, it's just for simplicity that we turn to "set of interconnected voxels = clusters" afterwards, as it facilitates the discussion. And it's for the same reason that we often combine a corrected voxel threshold with an arbitrary extent threshold of k voxels, we just don't have to talk about single-voxel findings (although they might well reflect true effects). But in fact, if you really have concerns about single-voxel or very-small-cluster findings then you shouldn't go with a corrected voxel threshold but an uncorrected voxel threshold combined with a cluster correction (or turn to something else like threshold-free cluster enhancement).

Best

Helmut

Top of Message | Previous Page | Permalink

JiscMail Tools


RSS Feeds and Sharing


Advanced Options


Archives

September 2019
August 2019
July 2019
June 2019
May 2019
April 2019
March 2019
February 2019
January 2019
December 2018
November 2018
October 2018
September 2018
August 2018
July 2018
June 2018
May 2018
April 2018
March 2018
February 2018
January 2018
December 2017
November 2017
October 2017
September 2017
August 2017
July 2017
June 2017
May 2017
April 2017
March 2017
February 2017
January 2017
December 2016
November 2016
October 2016
September 2016
August 2016
July 2016
June 2016
May 2016
April 2016
March 2016
February 2016
January 2016
December 2015
November 2015
October 2015
September 2015
August 2015
July 2015
June 2015
May 2015
April 2015
March 2015
February 2015
January 2015
December 2014
November 2014
October 2014
September 2014
August 2014
July 2014
June 2014
May 2014
April 2014
March 2014
February 2014
January 2014
December 2013
November 2013
October 2013
September 2013
August 2013
July 2013
June 2013
May 2013
April 2013
March 2013
February 2013
January 2013
December 2012
November 2012
October 2012
September 2012
August 2012
July 2012
June 2012
May 2012
April 2012
March 2012
February 2012
January 2012
December 2011
November 2011
October 2011
September 2011
August 2011
July 2011
June 2011
May 2011
April 2011
March 2011
February 2011
January 2011
December 2010
November 2010
October 2010
September 2010
August 2010
July 2010
June 2010
May 2010
April 2010
March 2010
February 2010
January 2010
December 2009
November 2009
October 2009
September 2009
August 2009
July 2009
June 2009
May 2009
April 2009
March 2009
February 2009
January 2009
December 2008
November 2008
October 2008
September 2008
August 2008
July 2008
June 2008
May 2008
April 2008
March 2008
February 2008
January 2008
December 2007
November 2007
October 2007
September 2007
August 2007
July 2007
June 2007
May 2007
April 2007
March 2007
February 2007
January 2007
2006
2005
2004
2003
2002
2001
2000
1999
1998


JiscMail is a Jisc service.

View our service policies at https://www.jiscmail.ac.uk/policyandsecurity/ and Jisc's privacy policy at https://www.jisc.ac.uk/website/privacy-notice

Secured by F-Secure Anti-Virus CataList Email List Search Powered by the LISTSERV Email List Manager