I have been trying to think of some reason why twinning could not be handled easily by MR algorithms, since we understand how twinning works and there's only one extra parameter (twin fraction alpha) to fit. Is it just something that's on the list but has not yet happened, or is there something more subtle to it that I am not thinking of? Yes, one can do MR on twinned data without accounting for twinning, but I would think the solutions would be much more obvious with twinning built in, and this would probably make a big difference in marginal cases.
Even SAD might be workable when the twin operator doesn't superimpose all Bijvoet mates on each other (I think this is possible).
All the best,
Jacob Keller
*******************************************
Jacob Pearson Keller, PhD
Looger Lab/HHMI Janelia Research Campus
19700 Helix Dr, Ashburn, VA 20147
email: [log in to unmask]
*******************************************
|