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FOOD DRINK NUTRITION DIET DIET FASTING:
Trial of First Fasting Mimicking Diet Safely Improves Biomarkers of Aging
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Trial of First Fasting Mimicking Diet Safely Improves Biomarkers of Aging
MedicalResearch.com
Medical Research Interviews and News
http://medicalresearch.com/author-interviews/trial-of-first-fasting-
mimicking-diet-safely-improves-biomarkers-of-aging/15300/
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A shorter URL for the above link:
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http://tinyurl.com/p7kf63z
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Medical Research: What is the background for this study?
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Dr. Longo: Despite health benefits, even short periods of fasting are
difficult to maintain for most people, as it can lead to electrolyte
abnormalities and malnutrition in at-risk individuals, such as the
elderly. ?For over a decade the Longo lab at the University of Southern
California has been studying effective approaches for achieving the
beneficial effects of fasting while avoiding its shortcomings. We recently
developed the first Fasting Mimicking Diet (FMD). Put in simple terms,
this five-day meal replacement regimen nourishes the organism while the
body thinks it is fasting. We tested this FMD in mice and in a pilot
randomized human trial with generally healthy subjects and found
impressive results around health optimization.
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snip
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Medical Research: What should clinicians and patients take away from your
report?
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Dr. Longo: Our results indicate that FMD cycles induce long-lasting
beneficial and/or rejuvenating effects in markers for diseases and
regeneration in humans. Although the clinical results will require
confirmation by a larger randomized trial, the effects of FMD cycles on
biomarkers/risk factors for aging, cancer, diabetes, and CVD, coupled with
the very high compliance to the diet and its safety, indicate that this
periodic dietary strategy has high potential to be effective in promoting
human healthspan. Because prolonged FMD such as the one tested here are
potent and broad-spectrum, they should only be considered for use under
medical supervision.
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Medical Research: What recommendations do you have for future research as
a result of this study?
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Dr. Longo: We are currently analyzing results from a larger clinical trial
on 70-80 subjects that includes additional end points to further support
the efficacy of our periodic FMD approach. Ultimately, we envision FMDs
getting FDA approval.
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Citation:
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A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration,
Enhanced Cognitive Performance, and Healthspan
Brandhorst, Sebastian et al.
Cell Metabolism
http://dx.doi.org/10.1016/j.cmet.2015.05.012
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The complete article may be read at the URL above.
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