We have recently changed from a urine methadone to urine EDDP assay (both on a Roche c501) and have received enquiries from the clinical users of our service who are seeing patients negative for EDDP but who were reliably positive for methadone in the past. Our local referral lab has confirmed absence of EDDP & presence of methadone in these samples (by GC-MS), commenting that sample adulteration seems likely.
There is some discussion on whether clients may be spiking their urine samples. One client is on daily supervised consumption. Have other labs had similar experiences when changing from urine methadone to EDDP assay? Is there any explanation other than adulteration?
Thanks for any help offered.
Royal Glamorgan Hospital
Cwm Taf University Health Board
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