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MEDICAL: DISEASES: AIDS HIV ACQUIRED IMMUNE DEFICIENCY :
MEDICAL: RESEARCH:
HIV Vaccine that Transforms Cell DNA Brings Fresh Hope
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HIV Vaccine that Transforms Cell DNA Brings Fresh Hope
By James Gallagher
BBC News
18 February 2015 Last updated at 12:14 ET
http://www.bbc.com/news/health-31511244
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A radical new approach to vaccination seems to completely protect monkeys
from HIV, US scientists report.
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Vaccines normally train the immune system to fight an infection.
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Instead, researchers at the Scripps Research Institute in California have
altered the DNA of monkeys to give their cells HIV-fighting properties.
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The team describe it as "a big deal" and want to start human trials soon.
Independent experts say the idea is worth "strong consideration".
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This technique uses gene therapy to introduce a new section of DNA inside
healthy muscle cells.
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That strip of DNA contains the instructions for manufacturing the tools to
neutralise HIV, which are then constantly pumped out into the bloodstream.
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Experiments, reported in the journal Nature, showed the monkeys were
protected from all types of HIV for at least 34 weeks.
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As there was also protection against very high doses, equivalent to the
amount of new virus that would be produced in a chronically infected
patient, the researchers believe the approach may be useful in people who
already have HIV.
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Lead researcher Prof Michael Farzan told the BBC: "We are closer than any
other approach to universal protection, but we still have hurdles,
primarily with safety for giving it to many, many people.
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The complete article may be read at the URL above.
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AAV-expressed eCD4-Ig provides durable protection
from multiple SHIV challenges
Matthew R. Gardner
1
*, Lisa M. Kattenhorn
2
*, Hema R. Kondur
1
, Markus von Schaewen
3
, Tatyana Dorfman
1
, Jessica J. Chiang
2
,
Kevin G. Haworth
4
, Julie M. Decker
5
, Michael D. Alpert
2,6
, Charles C. Bailey
1
, Ernest S. Neale Jr
2
, Christoph H. Fellinger
1
,
Vinita R. Joshi
1
, Sebastian P. Fuchs
7
, Jose M. Martinez-Navio
7
, Brian D. Quinlan
1
, Annie Y. Yao
2
, Hugo Mouquet
8,9
, Jason Gorman
10
,
Baoshan Zhang
10
, Pascal Poignard
11
, Michel C. Nussenzweig
8,12
, Dennis R. Burton
11,13
, Peter D. Kwong
10
, Michael Piatak Jr
14
,
Jeffrey D. Lifson
14
, Guangping Gao
15
, Ronald C. Desrosiers
2,7
, David T. Evans
16
, Beatrice H. Hahn
5
, Alexander Ploss
3
,
Paula M. Cannon
4
, Michael S. Seaman
17
& Michael Farzan
Nature
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14264.html
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