Pharmacoepidemiology Methods Workshop, Thursday 27th December 2014
Dunedin School of Medicine, New Zealand
Presenter: M. Alan Brookhart, PhD
Associate Professor of Epidemiology, Gillings School of Global Public Health
and Adjunct Associate Professor of Medicine, School of Medicine
University of North Carolina
With the growing availability of large healthcare databases, non-experimental studies of prescription medicines are becoming increasingly common. However, the appropriate design and analysis of such studies can be challenging. This workshop provides an intensive one-day introduction to the field of pharmacoepidemiological methods.
We begin by reviewing the data used in pharmacoepidemiology and the central threats to the validity of studies of medicines, including the healthy user bias, immortal person time bias, and various types of confounding bias. We will then discuss approaches to mitigate these biases through design and analysis. The workshop will cover the comparative new user design, self-controlled designs, propensity score methods, and instrumental variable approaches. We will also discuss some additional topics in the field, including studies of medication adherence, disparities, and active safety surveillance of medical products.
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