Related to better understanding GRADE: The US GRADE Network will be
hosting a 3-day workshop in Orlando, FL this fall. We are delighted to
have Gordon Guyatt join us.
Please see attached and distribute as you see fit.
Thank you
Ph*
Philipp Dahm, MD, MHSc, FACS
Professor of Urology,
University of Minnesota
Vice Chair of Veterans Affairs (VA)
Director for Surgery/Specialty
Care Service Line Research Activities
Coordinating Editor, Cochrane
Prostatic Diseases & Urological Cancers (PDUC) Group
Minneapolis VA Health Care
System, Urology Section 112D
One Veterans Drive
Minneapolis, MN 55417
E-mail: [log in to unmask]
On 7/28/14, 6:38 AM, "Pablo Alonso Coello" <[log in to unmask]> wrote:
>Phyll,
>
>A note of caution about that rule of thumb. GRADE also says that in
>general, we should not rate up for a large effect size if we have major
>concerns about other issues, including risk of bias, precision, and
>publication bias.
>
>A good read that you will probably find helpful is this one:
>http://www.jclinepi.com/article/S0895-4356(11)00184-3/fulltext
>
>For any other issues around GRADE the JCE series is available for free
>(http://www.gradeworkinggroup.org/publications/JCE_series.htm)
>
>Pablo
>
>
>Pablo Alonso Coello
>Centro Cochrane Iberoamericano
>Instituto de Investigación Biomédica (IIB Sant Pau)
>CIBER Epidemiología y Salud Pública (CIBERESP)
>C/ Sant Antoni Maria Claret 167 (Pabellón 18, planta cero)
>08025 Barcelona | España
>[log in to unmask] | Skype: tartanedo
>T: (+34) 93 553 78 14 | F: (+34) 93 553 78 09
>________________________________________
>De: Evidence based health (EBH) [[log in to unmask]] en
>nom de phyll buchanan [[log in to unmask]]
>Enviat el: dissabte, 26 / juliol / 2014 15:12
>Per a: [log in to unmask]
>Tema: Re: Looking for help on a SIDS paper
>
>Many thanks Ben, this is really helpful.
>
>Phyll
>
>
>> On 26 Jul 2014, at 13:48, "Djulbegovic, Benjamin"
>><[log in to unmask]> wrote:
>>
>> Phyll,
>> There is currently no consensus how large the effect size should be to
>>overcome concerns of bias ( and random error). Paul Glasziou has
>>suggested 10 times differences, GRADE suggests multiple studies with
>>effects size 2-5 times as large ( going in the same directions).
>> We have been trying to answer this question empirically, but so far
>>this has been hampered by lack of funding...
>> Hope this helps
>> Best
>> Ben
>>
>> Sent from my iPad
>> ( please excuse typos & brevity)
>>
>>> On Jul 26, 2014, at 8:41 AM, "Phyll Buchanan"
>>><[log in to unmask]> wrote:
>>>
>>> Any thoughts on how to decide whether the effect sizes are so large
>>>they should overcome these concerns?
|